(1) and (4) show optimistic cytotoxicity against EAC with IC50 of 9.63 and 11.25 µg/mL, respectively. Complexes (2) and (3) show promising cytotoxicityĪgainst EAC and HePG-2 cells with IC50 5.49 and 16.2 µg/mL, respectively. Results: Complex (5) shows the highest anticancer activity with IC50 of 5.15, 9.9, 13.1 and 17.7 µg/mLįor EAC, HePG-2, MCF-7 and HCT-116, respectively. In addition, anti-oxidation activity of the complexes was investigated. This feature is further supported by the DNAmetalĬomplexes binding ability. The ligand and its complexes were examined as anticancer agents against EhrlichĪscites carcinoma (EAC) and human cancer cells (hepatocellular carcinoma Hep-G2, mammary glandīreast cancer MCF-7 and colorectal carcinoma HCT-116). NO3 (5) were prepared and their structure was investigated by means of FTIR,ġH NMR, ESI-MS and UV-Vis spectra, elemental and thermal analysis, magnetic and molar conductance Their potential anticancer characteristics. Objective: To synthesize new metal complexes of 2-hydrazinobenzothiazole (hbt) and to investigate Need to explore and develop new metal-based anticancer drug molecules of high efficiency with less or Background: Due to the side effects of clinically approved anticancer drugs there is a great
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |